The objective of the study was to evaluate the role of cyanoacrylate glue in reducing dislodgement of umbilical venous catheters (UVCs).
It was a single-center, randomized, controlled, non-blinded trial. All infants requiring an UVC according to the local policy were included in the study. Infants with a UVC with a centrally located tip as verified by real-time ultrasound were eligible for the study. Primary outcome was the safety and efficacy of securement by cyanoacrylate glue plus cord-anchored suture (SG-group) vs. securement by suture alone (S-group), as measured by reduction in dislodgment of the external tract of the catheter. Secondary outcomes were tip migration, catheter-related bloodstream infection, and catheter-related thrombosis.
In the first 48 hours after UVC insertion, dislodgement was significantly higher in the S-group than in the SG-group (23.1% vs. 1.5%, P<0.001). The overall dislodgement rate was 24.6% in the S-group vs 7.7% in the SG-group (P=0.016). No differences were found in catheter-related bloodstream infection and catheter-related thrombosis. The incidence of tip migration was similar in both groups (S-group 12.2% vs. SG-group 11.7%).
The authors conclude that in the single-center study, cyanoacrylate glue was safe and effective for securement of UVCs, and particularly effective in reducing early catheter dislodgments.
Authors : Vito D’Andrea 1, Giorgia Prontera 2, Giovanni Pinna 3, Francesco Cota 2, Simona Fattore 2, Simonetta Costa 2, Martina Migliorato 2, Giovanni Barone 4, Mauro Pittiruti 5, Giovanni Vento 2
1. Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy. Electronic address: vito.dandrea@policlinicogemelli.it
2. Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy.
3. Neonatal intensive care unit, maternal-fetal department, “S. Camillo-Forlanini” Hospital, Rome, Italy.
4. Neonatal Intensive Care Unit, Infermi Hospital, Rimini, AUSL Romagna, Rimini, Italy.
5. Department of Surgery, Fondazione Policlinico Gemelli, Rome, Italy.
The Journal of Pediatrics (2023)
