The aim of this study is to describe the nationwide epidemiology of central-line-associated bloodstream infections (CLABSI) among Dutch Neonatal Intensive Care Units (NICUs).
Methods: Data from 2935 neonates born at <32 weeks’ gestation and/or with a birth weight <1500 g admitted to all nine Dutch NICUs over a two-year surveillance period (2019e2020) were analysed. Variations in baseline characteristics, CLABSI incidence per 1000 central-line days, pathogen distribution and CLABSI care bundles were evaluated. Multi-variable logistic mixed-modelling was used to identify significant predictors for CLABSI.
The conclusion of the study is that CLABSI remains a common problem in preterm infants in The Netherlands, with substantial variation in incidence between centres. Being the largest collection of data on the burden of neonatal CLABSI in The Netherlands, this epidemiological overview provides a solid foundation for the development of a collaborative platform for continuous surveillance, ideally leading to refinement of national evidence-based guidelines. Future efforts should focus on ensuring availability and extraction of routine patient data in aggregated formats.
Authors :
S.J. Jansen a, *, y, S.D.L. Broer a, y, M.A.C. Hemels b, D.H. Visser c, T.A.J. Antonius d, I.E. Heijting d, K.A. Bergman e, J.U.M. Termote f, M.C. Hu ̈tten g, J.P.F. van der Sluijs h, E.J. d’Haens b, R.F. Kornelisse j, E. Lopriore a, V. Bekker a
a Willem-Alexander Children’s Hospital, Department of Paediatrics, Division of Neonatology, Leiden University Medical Centre, The Netherlands
b Department of Neonatology, Isala, Zwolle, The Netherlands
c Emma Children’s Hospital, Department of Paediatrics, Division of Neonatology, Amsterdam University Medical Centre (AUMC), Location AMC, Amsterdam, The Netherlands
d Amalia Children’s Hospital, Department of Paediatrics, Division of Neonatology, Radboud University Medical Centre (Radboud UMC), Nijmegen, The Netherlands
e Beatrix Children’s Hospital, Department of Paediatrics, Division of Neonatology, University Medical Centre Groningen (UMCG), Groningen, The Netherlands
f Wilhelmina Children’s Hospital, Department of Neonatology, Division of Mother and Child, University Medical Centre Utrecht (UMCU), Utrecht, The Netherlands
g Department of Paediatrics, Division of Neonatology, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands h Department Paediatrics, Division of Neonatology, Ma ́xima Medical Centre (MMC), Veldhoven, The Netherlands
j Erasmus MC e Sophia Children’s Hospital, Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, University Medical Centre Rotterdam, Rotterdam, The Netherlands
* Corresponding author. Address: Leiden University Medical Centre, Department of Neonatology, PO Box 9600, 2300 RC Leiden, The Netherlands. Tel.: +31 0715269111.
E-mail address: s.j.jansen@lumc.nl (S.J. Jansen).
https://doi.org/10.1016/j.jhin.2023.11.020 
0195-6701/@ 2023 The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
