The intent of this document is to highlight practical recommendations in a concise format designed to assist acute-care hospitals in implementing and prioritizing their central line-associated bloodstream infection (CLABSI) prevention efforts. This document updates the Strategies to Prevent Central Line-Associated Bloodstream Infections in Acute-Care Hospitals published in 2014. This expert guidance document is sponsored by the Society for Healthcare Epidemiology of America (SHEA). It is the product of a collaborative effort led by SHEA, the Infectious Diseases Society of America (IDSA), the Association for Professionals in Infection Control and Epidemiology (APIC), the American Hospital Association (AHA), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise.

Authors: Niccolò Buetti MD, MSc, PhD, Jonas Marschall MD, MSc , Marci Drees MD, MS , Mohamad G. Fakih MD, MPH , Lynn Hadaway MEd, RN, NPD-BC, CRNI , Lisa L. Maragakis MD, MPH , Elizabeth Monsees PhD, MBA, RN, CIC , Shannon Novosad MD MPH, Naomi P. O’Grady MD, Mark E. Rupp MD , Joshua Wolf MBBS, PhD, FRACP, Deborah Yokoe MD, MPH and Leonard A. Mermel DO, ScM

Buetti N, et al. (2022). Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 Update. Infection Control & Hospital Epidemiology,
Author for correspondence: Dr. Leonard A. Mermel, E-mail: