The results of the analyses suggest that TLS reduced the incidence of CRBSIs without obvious adverse effects and bacterial resistance. There was insufficient evidence to demonstrate a difference in susceptibility to taurolidine between G+ and G-bacteria. As the analyses were limited to studies with small sample sizes, they cannot conclude whether TLS treatment is associated with a higher risk for catheter-associated thrombosis compared to a control heparin lock solution.
In addition, the results must also be treat with caution due to methodological deficiencies of the included studies. More well-designed and adequately powered RCTs are needed to confirm these findings.
Authors : Yong Liu1 *, An-Qiang Zhang2 , Lin Cao1 , Hong-Tao Xia1 , Jun-Jie Ma1
1 Intensive care unit, Suining Central Hospital, Chuanshan District, Suining, Sichuan, China,
2 State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, China
Liu Y, Zhang A-Q, Cao L, Xia H-T, Ma J-J (2013) Taurolidine Lock Solutions for the Prevention of Catheter-Related Bloodstream Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE 8(11): e79417.
