The use of cyanoacrylate for intravenous catheter securement is of interest to clinicians and patients, because of the superior adhesive strength and hemostatic effect of cyanoacrylate compared to current securement devices. The purpose of this study is to use novel in vitro and in vivo testing methods to analyze the hemostatic effect of a catheter securement cyanoacrylate (cyanoacrylate).
The cyanoacrylate rapidly achieved hemostasis in the presence of anticoagulated whole blood, platelet poor plasma, and non-anticoagulated whole blood, in vitro. The cyanoacrylate achieved hemostasis 12-fold faster than thromboplastin in the modified activated clotting time assay. The cyanoacrylate does not alter normal blood clotting, as measured by prothrombin time.
This study indicates that cyanoacrylate demonstrates a potent mechanical hemostatic effect and cyanoacrylate in the presence of anticoagulated whole blood has an activated clotting time that is 12 times quicker than thromboplastin. The cyanoacrylate was found to be significantly equivalent to two known hemostatic agents, in vivo.
Authors : Sheng Zhang1, Amanda R Guido1, Richard G Jones1, Benjamin J Curry2, Angela S Burke3 and Melanie E Blaisdell3
1 Adhezion Biomedical, LLC, Hudson, NC, USA
2 CirQuest Labs, LLC, Memphis, TN, USA
3 NAMSA, Northwood, OH, USA
Corresponding author : Sheng Zhang, Adhezion Biomedical, LLC, 506 Pine Mountain Road, Hudson, NC 28638, USA. Email: szhang@adhezion.com
The Journal of Vascular Access 2019, Vol. 20(1) 79–86
